Observations and comparison with 99mtco salivary 4 gland. Salivary gland anatomy n parotid gland n submandibular gland n sublingual gland n minor glands it is not our intent to cover anatomy during this course. Visual and quantitative comparisons of the patients scintigrams were made. The diagnostic value of technetium 99m pertechnetate salivary. Pdf salivary gland scintigraphy in gastroesophageal reflux.
The diagnostic value of salivary gland scintigraphy in patients without access to the salivary gland duct orfice is exemplified and discussed. They found that decreased secretion velocity in the parotid gland and decreased accumulation in the submandibular gland were sensitive indicators of salivary gland disease in. The tumors can arise in about 80% in parotid gland, 15% in submandibular gland and 5% in the sublingual and minor salivary gland. The fine anatomical and histological details will be covered in other courses.
Iv injection of technetium 99m pertechnetate concentrated in and excreated by glandular structures salivary, thyroid,mammary. Rosaidorfman disease rdd is an unusual clinical entity characterized by benign pseudolymphomatous proliferation with significant histiocytic infiltration. A new and rapid method of quantitative salivary gland scintigraphy has been developed. Pdf assessment of salivary gland function using salivary. In this study, a semiquantitative method providing 2 functional parameters for objective assessment of salivary gland function by scintillation camera imaging was tested.
Pdf salivary gland scintigraphy in gastroesophageal. Histopathologic grade 1 or 2 was found in 29 patients and grade 3 or 4 was found in 41 patients, and they were regarded as being in the early and advanced stages of sjogrens syndrome, respectively. Hereto, a lowradiation marker substance is administered. Full text get a printable copy pdf file of the complete article 647k, or click on a page image below to browse page by page. Salivary gland scintigraphy is a sensitive and valid method for evaluation of the function of the salivary glands. In 5 patients with suspected ss, the grades of 5 us measures of both parotid and submandibular salivary glands were scored 048 scale. These glands include the parotid and submandibular glands, located on both sides of the neck just below the ears and under the jaw. All patients were negative on their first fineneedle aspiration fna. Xerostomia was recorded according to the radiation therapy and oncology group rtog grade. Notice the similar uptake of the radionuclide in the normal thyroid lobes and salivary glands. Salivary gland scintigraphy sgs is a non invasive method of salivary gland function assessment. Seventytwo patients with benign parotid gland tumors n 52, malignant parotid tumors n 12, and inflammation n 8 underwent both fdg pet and salivary gland scintigraphy within 1 week, and 66 of the patients also underwent gallium scintigraphy. Quantitative salivary gland scientigraphy was performed using a standardized method.
Diagnostic value of salivary gland ultrasonographic. Value of quantitative salivary gland scintigraphy in the ear. Oct 16, 2015 scintigraphy nuclear medicine, pet functional study of salivary glands. Moreover, salivary gland scintigraphy is easy to perform, reproducible and welltolerated by the patient. The normal database consisted of 172 patients without any evidence of salivary gland malfunction. Sialagogue administered to evaluate secretory capacity. You will receive an injection of a lowlevel radioactive marker and will be positioned in front of or under a gamma scintillation camera, which detects. Salivary gland function scan parotid scintigraphy a salivary gland scan is a nuclear medicine test that evaluates the function of the salivary glands.
Ct values and salivary gland excretion in the submandibular. In such cases, the functional status of a gland can be assessed using scintigraphy. The substance accumulates in the salivary glands and emits radiation. Salivary gland scintigraphy in gastroesophageal reflux disease. Sjogren syndrome is a systemic autoimmune disease that mainly affects exocrine glands, such as the salivary and lacrimal glands, causing a decline in their secretions. The aim of this study was to investigate submandibular sialolithiasis with ct and scintigraphy, with a particular focus submandibular sialolithiasis with ct and scintigraphy. Because thyroid scintigraphy directly visualizes functional thyroid tissue, thyroid imaging can diagnose hyperthyroidism before laboratory tests are consistently abnormal. Study of quantitative oral radioactivity in salivary gland. The diagnosis of primary ss is still based on the medical history, physical examination, laboratory tests, salivary gland biopsy, and sialography or salivary gland scintigraphy. Part i 284 salivary gland scintigraphy salivary gland scintigraphy mwj versleijen, antoni van leeuwenhoek, amsterdam 1. Thyroid and salivary gland regions of interest were drawn to outline the entire circumference of each lobe of the thyroid gland and each zygomaticmolar salivary gland. A comparative study between mr sialography and salivary. Psychological tests medical outcomes study short form general health. Additionally, an abnormal salivary gland scintigraphy result is accepted by the americaneuropean consensus group as a criterion for the diagnosis of sjogrens syndrome.
It emphasises the functional salivary impairment, whichis ofgreat importance in theearly stages ofsalivary gland disease. Evaluation of salivary gland dysfunction using salivary. However, you should know the locations and characteristics of the salivary glands. However, its role as an independent investigative procedure in the evaluation of salivary gland dysfunction requires a study with larger sample size, which may yield a statistical. In patients with sjogren syndrome, 99mtcpertechnetate salivary gland scintigraphy showed a decrease in both excretion and uptake by the 4 glands. Specific feature like edge contrast enhancement especially helps in detection of radiolucent sialoliths. Considering a suv value 3 as being positive for malignancy and excluding warthins tumor on the basis of salivary gland scintigraphy, sensitivity and specificity of fdg pet were 75% and 80%, respectively. Improved quantification of salivary gland scintigraphy by means of factor analysis peter knoll1,2, gabriela krotla 2, brigitte bastati1, karl koriska, siroos mirzaei1 1department of nuclear medicine and pet center, wilhelminenspital. Rosaidorfman disease of the parotid and submandibular. The salivary gland scan, also called parotid gland scintigraphy, is a noninvasive test. Rosaidorfman disease of the parotid and submandibular glands. Sialography sialography is the radiographic visualization of the salivary gland following retrograde instillation of soluble contrast material into the ducts. The role of salivary gland scintigraphy in the evaluation.
Regarding the salivary gland excretion fraction using salivary gland scintigraphy, the data were digitally gathered and plotted on separate timeactivity curves for the submandibular glands, and the rois of each submandibular gland were drawn manually. This technique is easy to perform, reproducible and well tolerated by patients. Salivary gland scintigraphy was also performed on a group of 21 healthy subjects 8 women, men. A retrospective study was performed in 15 patients with dierent degrees of xerostomia and suspected salivary gland dysfunction. Methods in this paper we report on a validated acquisition protocol supplying a normal database for standardized quantitative salivary gland scintigraphy. Scintigraphy of the major salivary glands could therefore form part of the routine investigation of patients with sjogens syndrome. Compared with clinical and histological data, scintigraphy provides a sensitive method, even though it is not specific, for detecting minimal injuries to salivary glands in. Objective uptake of 99mtcpertechnetate in salivary glands reflects intact salivary gland parenchyma. Several studies for comparing the quantitative characteristics of salivary gland scintigraphy with the histopathologic grading.
Diagnostic value of fdg pet and salivary gland scintigraphy. Start studying thyroid, parathyroid, and salivary gland scintigraphy. Baishideng publishing group inc, 7041 koll center parkway, suite 160, pleasanton, ca 94566, usa. Of the few tests currently available for investigation of salivary gland function, sodium pertechnetate scintigraphy is a noninvasive one. Salivary gland scintigraphy plays a significant role in the evaluation of salivary gland dysfunction. Assessment of salivary gland function in sjogrens syndrome. To characterise the psychological profiles of sjogrens syndrome ss and patients with sicca symptoms but without ss.
Evaluation of salivary gland scintigraphy, magnetic resonance. Scintigraphy results correlate with clinical36 and histopathological features of the salivary glands in patients with ss. The role of salivary gland scintigraphy in the evaluation of. The close correlation between clinical manarrago, rain, brocheriou, rocher ifestations and scintigraphy indicates that salivary imagingis asuitable. These results were superior to those of gallium scintigraphy 58%.
Evaluation of diagnostic parameters from parotid and. The salivary gland excretion fraction was defined as a before stimulation test. However, it is difficult to follow patients with invasive tools, such as minor salivary gland biopsy or sialography. Pdf assessment of salivary gland function in sjogrens. In 1971, schall, et al 7 proposed a qualitative grade system for evaluating salivary gland function based on the results of quantitative analysis of 99mtcpertechnetate salivary gland scintigraphy, and subsequently, further grade systems were proposed 2022. Scintigraphysalivary gland scintigraphy uses tc99m pertechnetate which helps in assessment of salivary gland dysfunction in. The aim of the study was to evaluate the salivary gland dysfunction in a patient with uncontrolled type 2 diabetes using salivary gland scintigraphy. Goal the goal of gastrointestinal scintigraphy is to enable the interpreting physician to identify andor quantify anatomic or physiologic abnormalities of the salivary glands, gastrointestinal tract, or peritoneum.
The function of the sublingual glands and the minor. Evaluation of salivary gland scintigraphy, magnetic. The diagnosis of salivary gland disease relies mainly on the clinical presentation and in certain conditions on more specialized investigations. Technetium 99m pertechnetate salivary gland scintigraphy played a substantial role in the diagnosis and differential diagnosis of salivary gland diseases. It is typically performed in a hospital nuclear medicine department or outpatient radiology facility. However, its role as an independent investigative procedure in the evaluation of salivary gland dysfunction requires a study with a larger sample size, may yield a statistical significant result and it can also act as an adjunct along with. Regarding salivary gland scintigraphy, after intravenous injection of approximately 370 mbq of 99mtcpertechnetate, salivary gland scintigraphy was performed for 60 min with a gamma camera snc5100r and scintipack 24000.
Thyroid scintigraphy thyroid scan animal endocrine clinic. The role of salivary gland scintigraphy in detection of. Dynamic salivary gland scintigraphy started immediately after the i. Salivary scintigraphy was performed on 35 patients with head and neck cancer before the beginning of radiotherapy rt, and then at 6 weeks and again at 3 months after the completion of rt. Sensitivity and specificity of imaging modalities for sjogrens syndrome. Among patients with sialolithiasis, 99mtcpertechnetate salivary gland scintigraphy showed reduced excretion by the affected glands and decreased uptake in 5 patients. Salivary gland scintigraphy is widely accepted as a sensitive and valid method for evaluation of salivary gland dysfunction after radioactive iodine1 therapy rit. Value of quantitative salivary gland scintigraphy in the. Assessment of salivary gland function using salivary scintigraphy in pre and post radioactive iodine therapy in diagnosed thyroid carcinoma patients article pdf available. In the present study, sgs was performed in ss patients and in thyroid cancer patients postrai, and scintigraphic parameters were compared.
However, no standardized protocol for an accurate quantification of parenchymal function has been established so far. This article may be of use to technologists faced with. Salivary gland scintigraphy was also performed on 21 healthy subjects with no evidence of salivary gland malfunction. Scintigraphy nuclear medicine, pet functional study of salivary glands. Scintigraphy and the acrsnmspr practice guideline for the performance of liver and spleen scintigraphy. Submandibular sialolithiasis with ct and scintigraphy.
The result of this study leads to the conclusion that salivary gland scintigraphy plays a significant role in the evaluation of salivary gland dysfunction. Improved quantification of salivary gland scintigraphy by. In the patients with severe sjorgrens syndrome, uptake was 0. Salivary gland scintigraphy in sjogrens syndrome and. Salivary gland scintigraphy salivary gland scintigraphy mwj versleijen, antoni van leeuwenhoek, amsterdam 1. Introduction the selective uptake, accumulation and secretion of 99mtc pertechnetate by the salivary glands allow the function of the parotid and submandibular glands to be assessed. Infrequently performed studies in nuclear medicine. Scintigraphy of the salivary glands in sjogens syndrome. Department of radiation oncology, seoul national university college of medicine, seoul, korea. The uptake of pertechnetate in the glandular tissue and in a reference area in the neck are measured. Scintigraphy results correlate with clinical and histopathological features of the salivary glands in patients with ss. The necessity for careful dental examination and treatment in patients with an oroantral fistula is emphasised. Scintigraphy ofthe salivary glands in sjogens syndrome. Bleckmann and winfried brenner and j\anos mester and malte clausen, journaljournal of nuclear medicine technology, year1999, volume27 1, pages 206.